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PATOFISIOLOGI GNA

PATOFISIOLOGI GNA

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Published by Hamdan Hariawan

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Published by: Hamdan Hariawan on Oct 02, 2011
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09/25/2013

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PATOFISIOLOGI GLUMERULONEFRITIS

Infeksi atau penyakit ↓ Migrasi sel2 radang ke dalam glomerular ↓ Pembentukan kompleks antigen-antibodi dalam dinding kapiler ↓ Deposit complement & anttracs netrofil & monosit Enzim lysosomal merusak membran dasar gomerular Meningkatkan permeabilitas dinding glomerular Fibrinogen & plasma protein lain bermigrasi melalui dinding sel, Manifestasi klinis; proteinuria

Eritrosit bermigrasi melalui dinding sel yg rusak manifestasi; hematuria ↓ Proliferasi sel & fibrin yg terakumulasi dalam kapsula bowmans ↓ Menurunnya perfusi kapiler glomerular Manifestasi klinis; retensi cairan & meningkatnya BUN & creatinine

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